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| 1948 |
| | US lawyer Alger Hiss is denounced, controversially, as a Soviet spy | |
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| c. 1948 |
| | US psychologist B.F. Skinner trains laboratory rats to use their brains in his 'Skinnner box' | |
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| 1948 |
| | US president Harry S. Truman wins election to the office in his own right | |
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| 1949 |
| | The North Atlantic Treaty Organization (NATO) is set up by the USA and Canada, together with Britain and other European countries, for purposes of collective security | |
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| 1949 |
| | Annie Allen, by US author Gwendolyn Brooks, describes in narrative verse the life of a black girl in contemporary USA | |
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| 1949 |
| | Death of a Salesman, by US playwright Arthur Miller, has its first performance in New York | |
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| 1949 |
| | The musical South Pacific, by Richard Rodgers and Oscar Hammerstein II, opens on Broadway | |
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| 1949 |
| | US architect Philip Johnson builds the Glass House in Connecticut in the International Style | |
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| 1949 |
| | Gene Kelly, Frank Sinatra and Jules Munchin star as three US sailors on shore leave in the screen version of On the Town | |
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| 1949 |
| | The technique of radiocarbon dating is developed by US chemist Willard Libby | |
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